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Puromycin aminonucleoside
🥰Excellent
Catalog No. T16684Cas No. 58-60-6
Alias NSC 3056
Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
Puromycin aminonucleoside
🥰Excellent
Purity: 99.97%
Catalog No. T16684Alias NSC 3056Cas No. 58-60-6
Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $51 | In Stock | |
| 25 mg | $80 | In Stock | |
| 50 mg | $121 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $43 | In Stock |
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Purity:99.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner. |
| In vitro | Puromycin aminonucleoside -induced podocyte apoptosis is p53 dependent. Puromycin aminonucleoside causes podocyte apoptosis in a time-dependent manner. The IC50 values for PMAT-expressing and vector-transfected cells are 48.9 and 122.1 μM, respectively, suggesting expression of PMAT-enhanced cell sensitivity to Puromycin aminonucleoside. Puromycin aminonucleoside uptake in PMAT-expressing cells is fourfold higher at pH 6.6 than that at pH 7.4. Puromycin aminonucleoside (30 μg/mL) markedly enhances p53 protein levels in podocytes. Puromycin aminonucleoside (250 μM) is toxic to both PMAT-expressing and vector-transfected cells [2][4]. |
| In vivo | Rats administered Puromycin aminonucleoside (100 mg/kg, s.c.) exhibited reduced weight gain and elevated serum creatinine levels compared to controls. The podocyte count per glomerulus in control rats stood at 95.5±17.6, dropping to 90.7 by Day 4 in rats with Puromycin aminonucleoside (8 mg/100 g, i.v.)-induced nephrosis. Furthermore, nephrin levels per glomerulus in controls were 1.02±0.11 fmol, which decreased significantly in nephrosis rats to 0.46±0.06 fmol and 0.35±0.04 fmol on Days 4 and 7, respectively. This reduction in nephrin per podocyte was closely linked to proteinuria development in rats affected by Puromycin aminonucleoside nephrosis [5][6]. |
| Alias | NSC 3056 |
| Molecular Weight | 294.31 |
| Formula | C12H18N6O3 |
| Cas No. | 58-60-6 |
| Smiles | CN(C)c1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O |
| Relative Density. | 1.7 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 33.33 mg/mL (113.25 mM), Sonication is recommended. DMSO: 31 mg/mL (105.33 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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